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FLASH GENE
Symbol ULBP1 contributors: mct - updated : 28-11-2012
HGNC name UL16 binding protein 1
HGNC id 14893
Location 6q25.1      Physical location : 150.285.142 - 150.294.844
Synonym name
  • retinoic acid early transcript 1I
  • NKG2D ligand 1
    • Synonym symbol(s) RAET1I, ALCAN-beta, N2DL1, NKG2DL1
    DNA
    TYPE functioning gene
    STRUCTURE 9.70 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    text structure
  • ULBP1 promoter was inactive in the absence of the Sp proteins, indicating that Sp3 is the essential activator of ULBP1 transcription, because the overexpression of Sp3 up-regulated its promoter activity
    • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 3160 27.8 244 - 2006 1690190
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell
    cell lineage
    cell lines erythroleukemia cell lines, tumor cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES globular
    STRUCTURE
    motifs/domains
  • alpha 1 and alpha 2 domain
  • GPI domain
    • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to ulbp2
    homolog to ulbp3
    Homologene
    FAMILY
  • MHC class I family
    • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text glycosylphosphatidylinositol (GPI)-anchored
    basic FUNCTION
  • selective induction of ULBP1 expression by proteasome inhibitor drugs, along with variable KLRK1 ligand expression by human tumor cells, indicating that KLRK1 ligand genes are independently regulated
  • enhancing NK cell-mediated target recognition
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • target for the MARCH family of E3 ligases, MARCH4 and MARCH9, suggesting that induction of ULBP1 in response to heat shock is due to regulated association with its E3 ligases
  • GPI-linked ligand for natural cytotoxicity receptor KLRK1
  • involvement of TP53 in the regulation of specific ULBP1, ULBP2, ULBP3 that enhance NK cell-mediated target recognition
    • cell & other
    REGULATION
    activated by RAS activation that upregulates the expression of ULBP1, ULBP2, ULBP3
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    ULBP1 regulation may have implications for development of new therapeutic strategies against cancer cells
    ANIMAL & CELL MODELS