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FLASH GENE
Symbol BCAP31 contributors: mct/npt/pgu/shn - updated : 07-06-2013
HGNC name B-cell receptor-associated protein 31
HGNC id 16695
PROTEIN
PHYSICAL PROPERTIES Hydrophilic Hydrophobic
STRUCTURE
motifs/domains
  • N terminal hydrophobic region multiple membrane-spanning domains
  • three transmembrane domains
  • hydrophilic extracellular non glycosylated C terminal region with a KKXX coat protein I binding motif
  • mono polymer complex
    HOMOLOGY
    interspecies ortholog to Bcap31, Mus musculus
    ortholog to bcap31, Danio rerio
    ortholog to Bcap31, Rattus norvegicus
    Homologene
    FAMILY
  • BCAP29/BCAP31 family
  • CATEGORY chaperone/stress , antigen , protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text integral membrane protein of the endoplasmic reticulum
    basic FUNCTION
  • involved in the mitochondrion-endoplasmic reticulum cross talk through a Ca2+ dependent mechanism, via the generation of BAP20 by cleavage
  • putative cargo receptor protein BCAP31 participates in the transport and the quality control of human class I molecules
  • cargo receptor for ER export of some transmembrane proteins, especially those prone to (ER)-associated degradation (ERAD)
  • operates at early steps to deliver newly synthesized CFTR DeltaF508 to its degradation pathway
  • required to maintain PTPLB
  • role in the export of secreted proteins from the ER, the recognition of abnormally folded proteins, and their targeting to the ER-associated-degradation (ERAD) pathway
  • implicated in export of MHC class I molecules from the ER
  • involved in the control of maturation or trafficking of cystic fibrosis transmembrane conductance regulator
  • playing an important role in apoptosis, as a regulator of procaspase-8 processing and as a cleavage target of caspase-8
  • may play a role in regulating intracellular trafficking of ITGAM in neutrophils
  • essential for SV40 infection, required in a step after transport of the SV40 virus to the endoplasmic reticulum lumen, and after isomerization of disulphide bonds
  • required for dislocation of SV40 from the endoplasmic reticulum to the cytosol
  • the most abundant endoplasmic reticulum (ER) membrane protein
  • chaperone protein involved in several pathways, including ER-associated degradation, export of ER proteins to the Golgi apparatus, and programmed cell death
  • important role in ER-to-Golgi crosstalk
  • CDIP1/BCAP31-mediated regulation of mitochondrial apoptosis pathway represents a mechanism for establishing an ER-mitochondrial crosstalk for ER-stress-mediated apoptosis signaling 1)
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS immunity/defense , cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • part of a large hetero-oligomeric complex at he ER membrane
  • constituent of several large protein complexes
  • component of the ER quality control compartment and that it moves between the peripheral ER and a juxtanuclear ER or ER-related compartment distinct from the conventional ER-Golgi intermediate compartment
  • FIS1-BCAP31 complex (ARCosome) spanning the mitochondria-ER interface serves as a platform to activate the initiator procaspase-8, and thereby bridges two critical organelles for apoptosis signalling
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Cellubrevin
  • Bcl-2/Bcl-XL and procaspase-8
  • procaspase-8L
  • A4 protein
  • amma-actin and myosin B heavy chain
  • BAP29
  • bifunctional apoptosis regulator, BAR
  • protein tyrosine phosphatase-like B, PTPLB
  • caspase 8
  • CD11b/CD18
  • SEC61B and TRAM1
  • DERL1
  • Sec61
  • HPV E5 proteins
  • class I MHC molecules
  • MARCH proteins
  • Fission 1 homologue, Fis1
  • N-terminal peptide of VP2
  • BCAP31 is an interacting partner of CDIP1
  • cell & other
    REGULATION
    activated by cleavage by CASP8, generating the proapoptotic BAP20
    ASSOCIATED DISORDERS
    corresponding disease(s) DDCH
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer cells
    constitutional        
    loss of BCAP31 is potentially related to liver dysfunction and hearing loss
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS