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FLASH GENE

Symbol

SH3BGRL2

contributors: npt - updated : 09-05-2007

HGNC name	SH3 domain binding glutamic acid-rich protein like 2
HGNC id	15567

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6q13-15      Physical location : 80.340.999 - 80.413.369
Synonym name	fovea-associated SH3 domain binding protein
Synonym symbol(s)	FLJ90025, FASH3

DNA

TYPE	functioning gene
STRUCTURE	72.37 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed SH3BGRL2 4 - 4675 12.2 107 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive intestine large intestine       Reproductive male system prostate       Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage
cell lines
fluid/secretion	blood

at STAGE

physiological period

embryo

Text	stem cells

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a SH3-binding domain
	a glutamic acid-rich protein motif

HOMOLOGY

intraspecies

homolog to SH3BGR

Homologene

FAMILY

SH3BGR family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	may be functioning as endogenous modulators of glutaredoxin activity
	may participate in globin regulation and may be important in the normal physiology of erythrocytes (De Andrade 2010)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS