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FLASH GENE

Symbol

POU6F1

contributors: - updated : 13-04-2006

HGNC name	POU domain, class 6, transcription factor 1
HGNC id	9224

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12q13.1      Physical location : 51.580.719 - 51.611.477
Synonym symbol(s)	BRN5, MPOU,TCFB1

DNA

TYPE	functioning gene
STRUCTURE	7.00 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth tongue     highly   salivary gland       highly Lymphoid/Immune spleen       highly Nervous brain forebrain cerebral cortex   highly   brain diencephalon hypothalamus   highly   brain hindbrain cerebellum   highly Olfactory olfactory bulb

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose       Muscular striatum skeletal     Nervous central

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo, fetal, pregnancy

Text	Rathke pouch, at an early stage of pituitary development ,developping brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

POU specific and POU homeo (helix-turn-helix) domains

mono polymer

homomer , heteromer , dimer

HOMOLOGY

interspecies	homolog to Drosophila bicoid
	homolog to murine Pou6f1
	homolog to C.elegans k02b12.1

Homologene

FAMILY	homeo box backfoot
	class VI POU homeodomain family of transcription factors

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	playing a role in regulating TCR beta gene expression
	playing a role in regulating lymphoid gene expression

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

development

text	brain, heart, muscle development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA	binding preferentially to a variant of the octamer motif (ATGATAAT)
	binding to a critical motif in the T-cell receptor (TCR) beta enhancer

RNA

small molecule

protein

bound to Pit-1 binding elements of the PRL gene (involved in the activation of PRL by cAMP through 1P in the presence of Pit-1)

cell & other

REGULATION

repressed by

expressed with POMC in a subset of adult anterior pituitary cells

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS