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FLASH GENE

Symbol

SORCS3

contributors: shn/npt - updated : 07-07-2020

HGNC name	sortilin-related VPS10 domain containing receptor 3
HGNC id	16699

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       a neurological phenotype including infantile spasms, intellectual disability, global developmental delay, microcephaly, hypotonia, spastic quadriplegia, and delayed myelination

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Sorcs3-deficient mice suffer from deficits in behavioral activities associated with hippocampal long-term depression (LTD), particularly from an accelerated extinction of fear memory