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FLASH GENE
Symbol KCNK12 contributors: mct/npt - updated : 25-11-2015
HGNC name potassium channel, subfamily K, member 12
HGNC id 6274
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • highly conserved 19AA region in its N terminus (AAs 6-24 in the rat orthologue) that is missing in the closely related channel KCNK13
  • cytoplasmic N-terminal region (Nt-THIK2) contains an arginine-rich motif (RRSRRR) that acts as a retention/retrieval signal
    • HOMOLOGY
    intraspecies homolog to KCNK13 (60 p100)
    Homologene
    FAMILY
  • two pore domain potassium channel family
  • potassium channel subfamily K (KCNK family)
    • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text mainly localised to the endoplasmic reticulum
    basic FUNCTION
  • may be involved in both the maintenance of neuronal phenotype and in the specific functional role of these neurons in their respective networks (Jezzini 2004)
  • KCNK12, KCNK13 form active heteromeric channels, further expanding the known repertoire of K(+) channels
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text
  • ion transport
  • potassium channel
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other phosphorylation-dependent regulation of KCNK12 trafficking
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS