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FLASH GENE

Symbol

KCNK12

contributors: mct/npt - updated : 25-11-2015

HGNC name	potassium channel, subfamily K, member 12
HGNC id	6274

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	53.76 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_022055 2 - 1449 NP_071338 46.9 430 - 2008 18209473

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas         Nervous brain         Urinary kidney tubule collecting duct     Homo sapiens   kidney tubule convoluted tubule     Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	highly conserved 19AA region in its N terminus (AAs 6-24 in the rat orthologue) that is missing in the closely related channel KCNK13
	cytoplasmic N-terminal region (Nt-THIK2) contains an arginine-rich motif (RRSRRR) that acts as a retention/retrieval signal

HOMOLOGY

intraspecies

homolog to KCNK13 (60 p100)

Homologene

FAMILY	two pore domain potassium channel family
	potassium channel subfamily K (KCNK family)

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum
text	mainly localised to the endoplasmic reticulum

basic FUNCTION	may be involved in both the maintenance of neuronal phenotype and in the specific functional role of these neurons in their respective networks (Jezzini 2004)
	KCNK12, KCNK13 form active heteromeric channels, further expanding the known repertoire of K(+) channels

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	ion transport
	potassium channel

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

Other

phosphorylation-dependent regulation of KCNK12 trafficking

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS