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FLASH GENE

Symbol

JAM2

contributors: mct - updated : 24-08-2020

HGNC name	junctional adhesion molecule 2
HGNC id	14686

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	78.28 kb     10 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_021219 10 - 4357 NP_067042 30.8 298 - 2003 14519386 NM_001270407 9 - 4249 NP_001257336 - 262 - 2003 14519386 NM_001270408 10 - 1747 NP_001257337 - 312 - 2003 14519386

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       predominantly Homo sapiens Lymphoid/Immune lymphatic vessel         Homo sapiens Adult   tonsils         Reproductive female system uterus     highly Homo sapiens Adult

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Homo sapiens Adult Epithelial barrier lining endometrium     Homo sapiens Adult

cells

System Cell Pubmed Species Stage Rna symbol Cardiovascular endothelial cell Homo sapiens Adult

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two Ig-like folds
	three N-linked glycosylation site in the extracellular domain
	a C terminal short tail with a PDZ domain

conjugated

GlycoP

HOMOLOGY

interspecies

homolog to murine Jcam2

Homologene

FAMILY	immunoglobulin superfamily
	JAM family

CATEGORY

adhesion

SUBCELLULAR LOCALIZATION	plasma membrane,junction,tight
text	integral transmembrane protein of tight junction,colocalizing with F actin at membrane ruffles

basic FUNCTION	may be involved in adhesion events associated with cardiac inflammatory conditions
	JAM1, JAM2, JAM3 expressions on the lymphatic endothelium may contribute to both seal the cell-cell contact at interendothelial junctions
	play an important role in the assembly and maintenance of tight junctions and in the establishment of epithelial cell polarity
	identifies a unique population of RGCs (retinal ganglion cells) in which structure corresponds remarkably to function
	appears to contribute to leucocyte extravasation by facilitating not only transmigration but also rolling and adhesion
	is an active player in the maintenance of the bone marrow stromal microenvironment
	JAMB and JAMC are potentially essential for vertebrate myocyte fusion
	may play a role in the interaction between hatched blastocyst and receptive uterus
	role of JAM2, JAM3 in progression of gastric adenocarcinoma
	may function as a putative tumour suppressor in the progression and metastasis of colorectal cancer
	is an adhesive ligand interacting with various immune cell types and regulating vascular function and was recently identified as an inhibitor of somatodendritic myelination in spinal cord neurons

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

inflammation

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	integrin alpha 4 beta 1 facilitated by JAM3
	interactions with JAM2 and JAM3 are essential for development of cutaneous inflammation
	high affinity JAM3 ligand
	functional adhesive interaction between JAM2 and JAM3 is found between human hematopoietic stem and progenitor cells (HSPC) and mesenchymal stem cells

cell & other

adhering to T, NK, dendritic cells

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

BGCI8

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   aberrantly expressed in glioma

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer brain   potential of JAM3 and JAM2 as new targets for the treatment of human gliomas

ANIMAL & CELL MODELS

Jam-b-deficient mice have defects in the regulation of hematopoietic stem cell pool