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FLASH GENE

Symbol

GPR63

contributors: mct/npt - updated : 06-05-2010

HGNC name	G protein-coupled receptor 63
HGNC id	13302

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6q16.1      Physical location : 97.245.888 - 97.285.353
Synonym name	brain expressed G-protein-coupled receptor PSP24 beta
Synonym symbol(s)	PSP24B, PSP24(beta), PSP24-2

DNA

TYPE	functioning gene
STRUCTURE	39.47 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001143957 3 - 2198 NP_001137429 47.4 419 - Niedernberg (2003) NM_030784 2 - 2080 NP_110411 - 419 - Niedernberg (2003)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain diencephalon hypothalamus   lowly   brain forebrain cerebral cortex frontal     brain basal nuclei caudate nucleus   lowly   brain limbic system hippocampus   highly   brain midbrain     lowly

cells

System Cell Pubmed Species Stage Rna symbol Nervous pyramidal cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane domains

HOMOLOGY

interspecies

homolog to murine Gpr63

Homologene

FAMILY

G-protein coupled receptor 1 family

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

transducing extracellular signals through heterotrimeric G proteins

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

activated by

S1P, dihydro-S1P and dioleoylphosphatidic acid (Niedernberg 2003)

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS