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FLASH GENE

Symbol

PDE2A

contributors: mct - updated : 10-01-2018

HGNC name	phosphodiesterase 2A, cGMP-stimulated
HGNC id	8777

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

COCH

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   may provide a brake against the inhibitory action of NPPB on sympathetic transmission constitutional     --over   in failing hearts and desensitizes against ADRB1 stimulation

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed psychiatry     PDE2A inhibitors could be used as pharmacological drugs for treatment of anxiety and nicotine addiction via their actions on medial habenula (MHb) axonal terminals miscelleaneous vascular   targeting PDE2A may provide a new therapeutic approach in diseases associated with endothelial dysfunction, oxidative stress, vascular proliferation, and angiogenesis respiratory     inhibition of PDE2A is of potential therapeutic interest in sepsis and acute respiratory distress syndrome (ARDS)

ANIMAL & CELL MODELS