| SUBCELLULAR LOCALIZATION
| extracellular
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| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,inner
|
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| intracellular,cytoplasm,organelle,mitochondria,outer
|
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| intracellular,cytoplasm,organelle,mitochondria,matrix
|
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| intracellular,cytoplasm,organelle,membrane
|
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| intracellular,cytoplasm,organelle,Golgi
|
|
| intracellular,cytoplasm,cytosolic
|
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| intracellular,cytoplasm,cytoskeleton,microtubule
|
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| intracellular,nucleus
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| text
| localizes to synaptosomal membranes  |
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with GUCA1A are coexpressed in the same population of the olfactory sensory neurons |
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presence of GUCY2D, GUCA1A, and PDE2A predominant in the cilia, yet to a lesser degree, they are also present in other regions of the olfactory neurons |
| basic FUNCTION
| having 3',5'-cyclic nucleotide phosphodiesterase activity |
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hydrolyzing both cyclic AMP (cAMP) and cyclic GMP (cGMP) |
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potentially TNF-alpha-mediated up-regulation of PDE2A may destabilize endothelial barrier function in sepsis |
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regulates the basal cGMP concentration in thalamic neurons |
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promotes activation of NADPH oxidase-dependent ROS production and subsequent endothelial proliferation and angiogenesis |
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plays a fundamental role in signal transduction |
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plays a major role in regulating dopamine-stimulated cAMP production in striatal neurons |
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preferential distribution of PDE2A into axons and terminals of the principal neurons suggests roles in regulation of axonal excitability or transmitter release |
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PDE2A serves likely as the downstream transducer of cGMP signals produced by NPR1 activation |
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PDE2A performs likely the important function of regulating neurotransmitter release by negatively linking cGMP signals to the cAMP pathway |
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appears to play an important role in growth and invasion of the human malignant melanoma PMP cell line |
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exerts its action on cognitive processes via the control of intracellular second messengers, cGMP and, to a lesser extent, cAMP |
