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FLASH GENE

Symbol

GPSM3

contributors: mct - updated : 23-01-2024

HGNC name	G-protein signaling modulator 3 (AGS3-like, C. elegans)
HGNC id	13945

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional         resulted in mild but significant neutropenia and leukocytosis tumoral     --over   in low-grade glioma and negatively correlated to the GPSM3 DNA methylation

Susceptibility

to rheumatoid arthritis

Variant & Polymorphism other	SNPs rs204989 and rs204991, each previously associated with protection from rheumatoid arthritis

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Gpsm3-deficient mice exhibit a profoundly blunted course of joint damage in an acute, collagen antibody-induced model of inflammatory arthritis