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FLASH GENE

Symbol

GPSM3

contributors: mct - updated : 23-01-2024

HGNC name	G-protein signaling modulator 3 (AGS3-like, C. elegans)
HGNC id	13945

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_022107 8 - 1456 NP_071390 - 160 - 2004 15096500 NM_001276501 4 - 1213 NP_001263430 - 160 - 2004 15096500

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Lymphoid/Immune lymph node       highly   spleen       highly   thymus       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal region is a novel G protein-interacting domain that may have distinct regulatory effects within the G(i/o) subfamily, and thus, it could potentially play a role in differentiating signals between these related G proteins
	three G-protein regulatory motifs downstream of an amino terminus domain with multiple prolines
	two GoLoco motifs to exert GDP dissociation inhibitor activity over Galpha(i) subunits

HOMOLOGY

interspecies

homolog to murine Gpsm3

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm

basic FUNCTION	having GTPase activator activity
	GPSM3 acts as a direct negative regulator of NLRP3 function
	is a regulator of G protein-coupled receptor signaling, with expression restricted to leukocytes and lymphoid organs
	potential role for GPSM3 in the development of inflammation in rheumatoid arthritis, most likely through a key regulatory role on leukocyte chemotaxis to the synovium

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	GPSM3 also interacts directly with numerous members of the 14-3-3 protein family, and this interaction is dependent on GPSM3 phosphorylation
	GPSM3 is a NLRP3-interacting protein and a negative regulator of IL1B production triggered by NLRP3-dependent inflammasome activators
	binding of GPSM3 to RGS5 appears to be selective as no interactions were detected with other RGS proteins

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional         resulted in mild but significant neutropenia and leukocytosis tumoral     --over   in low-grade glioma and negatively correlated to the GPSM3 DNA methylation

Susceptibility

to rheumatoid arthritis

Variant & Polymorphism other	SNPs rs204989 and rs204991, each previously associated with protection from rheumatoid arthritis

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Gpsm3-deficient mice exhibit a profoundly blunted course of joint damage in an acute, collagen antibody-induced model of inflammatory arthritis