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FLASH GENE
Symbol GPSM3 contributors: mct - updated : 23-01-2024
HGNC name G-protein signaling modulator 3 (AGS3-like, C. elegans)
HGNC id 13945
Location 6p21.32      Physical location : 3.419.561 - 32.163.300
Synonym name
  • chromosome 6 open reading frame 9
  • activator of G-protein signaling 4
    • Synonym symbol(s) G18, NG1, G18.2, G18.1A, G18.1B, C6orf9, AGS4
    DNA
    TYPE functioning gene
    STRUCTURE 4.76 kb     8 Exon(s)
    regulatory sequence cytosine-phosphate-guanine/HTF
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1456 - 160 - 2004 15096500
    4 - 1213 - 160 - 2004 15096500
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Lymphoid/Immunelymph node   highly
     spleen   highly
     thymus   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal region is a novel G protein-interacting domain that may have distinct regulatory effects within the G(i/o) subfamily, and thus, it could potentially play a role in differentiating signals between these related G proteins
  • three G-protein regulatory motifs downstream of an amino terminus domain with multiple prolines
  • two GoLoco motifs to exert GDP dissociation inhibitor activity over Galpha(i) subunits
    • HOMOLOGY
    interspecies homolog to murine Gpsm3
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • having GTPase activator activity
  • GPSM3 acts as a direct negative regulator of NLRP3 function
  • is a regulator of G protein-coupled receptor signaling, with expression restricted to leukocytes and lymphoid organs
  • potential role for GPSM3 in the development of inflammation in rheumatoid arthritis, most likely through a key regulatory role on leukocyte chemotaxis to the synovium
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GPSM3 also interacts directly with numerous members of the 14-3-3 protein family, and this interaction is dependent on GPSM3 phosphorylation
  • GPSM3 is a NLRP3-interacting protein and a negative regulator of IL1B production triggered by NLRP3-dependent inflammasome activators
  • binding of GPSM3 to RGS5 appears to be selective as no interactions were detected with other RGS proteins
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    resulted in mild but significant neutropenia and leukocytosis
    tumoral     --over  
    in low-grade glioma and negatively correlated to the GPSM3 DNA methylation
    Susceptibility to rheumatoid arthritis
    Variant & Polymorphism other
  • SNPs rs204989 and rs204991, each previously associated with protection from rheumatoid arthritis
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Gpsm3-deficient mice exhibit a profoundly blunted course of joint damage in an acute, collagen antibody-induced model of inflammatory arthritis