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FLASH GENE
Symbol AKR1B10 contributors: mct/pgu - updated : 18-02-2012
HGNC name aldo-keto reductase family 1, member B10 (aldose reductase)
HGNC id 382
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer monomer
HOMOLOGY
interspecies homolog to rattus Akr1b10 (82.6pc)
Homologene
FAMILY
  • aldo-keto reductase superfamily
  • CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • aldo-ketoreductase reducing aromatic and aliphatic aldehydes, less active on hexoses
  • playing a critical role in the growth and proliferation of cancer cells by detoxifying reactive carbonyls and regulating fatty acid biosynthesis
  • may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs
  • may regulate cell proliferation and cellular response to additional carbonyl stress
  • regulates the stability of acetyl-coA carboxylase-alpha and is a novel regulator of the biosynthesis of fatty acid in breast cancer cells
  • may play a greater role in lung carcinogenesis through dysregulation of reinoic acid homeostasis than through oxidation of PAH trans-dihydrodiols
  • dysregulated in Barrett's esophagus and esophageal adenocarcinoma
  • might be useful as a new marker for identification of high lung cancer risk patients in usual interstitial pneumonia
  • may play an important role in tumor progression or drug resistance
  • new secretory protein belonging to a lysosome-mediated non-classical protein-secretion pathway and is a potential serum marker
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NFE2L2 is one of the major factors involved in the AKR1B10 gene regulation
  • selective target for modification and inhibition by prostaglandin A(1)
  • cell & other
    REGULATION
    Other regulated by NFE2L2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinoma, lung squamous carcinoma and lung adenocarcinoma in smokers
    tumoral     --over  
    high expression of AKR1B10 reflects a less aggressive tumour behaviour, in hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS