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FLASH GENE
Symbol AKR1B10 contributors: mct/pgu - updated : 18-02-2012
HGNC name aldo-keto reductase family 1, member B10 (aldose reductase)
HGNC id 382
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus    
Digestiveintestinesmall intestine  highly Homo sapiens
 intestinelarge intestinecolon highly Homo sapiens
 liver    
Endocrineadrenal gland   highly
Reproductivemale systemprostate   
 male systemtestis   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer monomer
HOMOLOGY
interspecies homolog to rattus Akr1b10 (82.6pc)
Homologene
FAMILY
  • aldo-keto reductase superfamily
  • CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • aldo-ketoreductase reducing aromatic and aliphatic aldehydes, less active on hexoses
  • playing a critical role in the growth and proliferation of cancer cells by detoxifying reactive carbonyls and regulating fatty acid biosynthesis
  • may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs
  • may regulate cell proliferation and cellular response to additional carbonyl stress
  • regulates the stability of acetyl-coA carboxylase-alpha and is a novel regulator of the biosynthesis of fatty acid in breast cancer cells
  • may play a greater role in lung carcinogenesis through dysregulation of reinoic acid homeostasis than through oxidation of PAH trans-dihydrodiols
  • dysregulated in Barrett's esophagus and esophageal adenocarcinoma
  • might be useful as a new marker for identification of high lung cancer risk patients in usual interstitial pneumonia
  • may play an important role in tumor progression or drug resistance
  • new secretory protein belonging to a lysosome-mediated non-classical protein-secretion pathway and is a potential serum marker
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NFE2L2 is one of the major factors involved in the AKR1B10 gene regulation
  • selective target for modification and inhibition by prostaglandin A(1)
  • cell & other
    REGULATION
    Other regulated by NFE2L2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinoma, lung squamous carcinoma and lung adenocarcinoma in smokers
    tumoral     --over  
    high expression of AKR1B10 reflects a less aggressive tumour behaviour, in hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS