Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

WNK4

contributors: mct/pgu - updated : 23-09-2018

HGNC name	WNK lysine deficient protein kinase 4
HGNC id	14544

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

PHA2B

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   markedly augmented TRPC3-mediated Ca(2+) influx in vascular smooth muscle cells (VSMCs), which is the pathological hallmark of hypertension in resistance arteries

Susceptibility

to essential hypertension to osteoporosis

Variant & Polymorphism SNP	polymorphism rs56116165 is a rare allelic variant in a candidate gene with a biological function in renal calcium homeostasis that may contribute to a genetic predisposition to osteoporosis

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS