protein
| SLC26A6 (regulating SLC26A6) |
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SLC12A3 and KCNJ1 (inhibition of activity of SLC12A3 and KCNJ1) |
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activating STK39 and OSR1 |
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interactingw ith ITSN1, leading to endocytosis of KCNJ1 |
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interacts with WNK3 and WNK1 to regulate SLC12A3 in both human kidney cells and Xenopus oocytes |
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interaction between WNK4 and PKC regulation of TRPV5 may be important for physiological regulation of renal Ca2+ reabsorption by parathyroid hormones or the tissue kallikrein |
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enhances the surface expression of epithelial Ca2+ channel TRPV5, which plays a key role in the fine tuning of renal Ca2+ reabsorption |
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SLC9A3R2 acts synergistically with WNK4 by stabilizing TRPV5 at the plasma membrane to maintain the positive regulation of WNK4 on TRPV5 |
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inhibits KCNMA1 activity by reducing KCNMA1 protein at the membrane, but the inhibition is not due to an increase in clathrin-mediated endocytosis of KCNMA1, but likely due to enhancing its lysosomal degradation |
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modulates the activity of the renal Na(+)Cl(-) cotransporter SLC12A3 |
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KLHL3 inhibited the positive effect of WNK4 on Na(+)-Cl(-) cotransporter (NCC) by decreasing WNK4 protein abundance |
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inhibits large conductance, Ca2+-activated K+ channels activity, in part, by increasing channel degradation through an ubiquitin-dependent pathway |
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WNK4 is a substrate for KLHL3-CUL3 E3 ubiquitin ligase complexes |
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attenuates plasma membrane targeting of SLC12A3 through regulation of STX12 SNARE complex formation with VAMP2 in recycling and sorting endosome |
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WNK1 and WNK4 are the targets for the KLHL3-CUL3 complex and modulate the activity of SLC12A5 by means of intermediary Ste20-type kinases known as STK39 or OSR1 |
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WNK4 and PP1 regulate SLC12A7 activity as part of a common signaling module, but that they do not exert their effects through STK39 or carrier dephosphorylation |
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CLDN7 plays an important role in salt balance in renal collecting duct (CD) cells and modulating WNK4 and SCNN1A expression levels that are vital in controlling salt-sensitive hypertension |
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