| basic FUNCTION
| cytoplasmic serine-threonine kinase containing cysteine in place of the lysine found at the conserved ATP-binding location in subdomain II of protein kinases |
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involved in the modulation of growth factor-induced cancer cell proliferation through the MAP2K1/ERK1/2 pathway  |
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candidate tumor suppressor gene, having potentially a coordinated activity of WNK kinases in the regulation of cell proliferation |
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cell growth regulator that modulates activation of the ERK1/2 protein kinase and is epigenetically silenced in gliomas |
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controls a RhoA-mediated cross-talk mechanism that regulates the efficiency with which MAP2K1 can activate ERK1/2 upon growth factor stimulation |
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with WNK1, WNK3, WNK4, have vital roles in the control of salt homeostasis and blood pressure |
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negatively regulate epidermal growth factor receptor signaling via inhibition of MAP2K1 |
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role for WNK2 in the regulation of SLC12A2, SLC12A5 in the mammalian brain, with implications for both cell volume regulation and/or GABAergic signaling |
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might activate SLC12A2 indirectly via STK39 |
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control GTP-loading of RAC1, a signalling guanosine triphosphatase involved in cell migration and motility |
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tumour-suppressing role of WNK2 that is related to RAC1 signalling and tumour cell invasion and proliferation |
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important role for WNK2 in the control of glia-derived cell migration and tumorigenic growth |
