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FLASH GENE

Symbol

WNK1

contributors: mct/npt/pgu - updated : 20-10-2016

HGNC name	WNK lysine deficient protein kinase 1
HGNC id	14540

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	Wnk1(-/-) embryos can be rescued by endothelial-specific expression of a constitutively active form of the WNK1 substrate protein kinase OSR1 (oxidative stress responsive 1)
	endothelial-specific deletion of Wnk1 in mice results in embryonic lethality, with angiogenesis and cardiac defects beginning at embryonic day &
	8764;10.5