motifs/domains
| catalytic domain near the N terminus, including the unique sequence variation around catalytically important lysine residues that characterize the WNK subfamily (N-terminal region is required for protein complex formation with TBC1D4) |
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serine/threonine protein kinase |
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a catalytic domain containing a cysteine in place of a lysine in catalytic subdomain II, the WNK sequence signature within the subdomains I and II |
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several phosphorylation sites |
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PY motifs, which bind the E3 ubiquitin ligase NEDD4L |
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regulatory C-terminal including a highly conserved acidic motif and two coil-coil domains, and C-terminal WNK1 fragments can be phosphorylated by OXSR1, suggesting that OXSR1 catalyzes feedback phosphorylation of WNK1 |
| basic FUNCTION
| may be involved in osmotic control |
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may be able to influence ion homeostasis through its effects on synaptotagmin function |
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mediating with STK39, and OXSR1 the hypotonic stress signaling pathway to the transporters and may provide insights into the mechanisms by which WNK1 regulates ion balance |
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with WNK2, WNK3, WNK4, have vital roles in the control of salt homeostasis and blood pressure |
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when activated, subsequently phosphorylate and activate the related protein kinases STK39 and OXSR1 |
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signaling molecule involved in regulation of LINGO1 mediated inhibition of neurite extension |
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controls sodium and chloride ion transport by inhibiting the activity of WNK4 |
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may also play a role in actin cytoskeletal reorganization |
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regulate many ion transport proteins by altering membrane trafficking by activating SGK1 to inhibit Nedd4-mediated internalization of the epithelial Na+ channel |
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involved in the regulation of SLC2A11, which secures glucose transport in noninsulin target cells |
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may exert its mitotic function through its enzymatic activity, protein-protein associations, or likely both |
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potential mitotic kinase regulating both the formation of mitotic spindles and the completion of abscission |
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WNK1 activation of the OSR1 signaling cascade is likely an essential pathway that regulates angiogenesis and cardiac formation during development |
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functions as a chloride sensor through direct binding of a regulatory chloride ion to the active site, which inhibits autophosphorylation |
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mediates aldosterone-dependent activity of the WNK/SPAK/OSR1 pathway |
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WNK1 is a negative regulator of integrin-mediated adhesion, whereas it acts as a positive regulator of migration via the kinases OXSR1 and STK39 and the ion co-transporter SLC12A2 |
