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FLASH GENE

Symbol

S100A10

contributors: mct - updated : 14-04-2015

HGNC name	S100 calcium binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11))
HGNC id	10487

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive liver           pharynx       highly Hearing/Equilibrium ear       highly Nervous brain limbic system hippocampus dentate gyrus   Homo sapiens Reproductive female system breast mammary gland   highly Visual eye lens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective interstitial dermis     Epithelial barrier/lining

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two calcium binding domains
	an EF-hand motif
	one S100 specific N ter
	one classical C ter

mono polymer

tetramer

HOMOLOGY

Homologene

FAMILY

S-100 family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
text	S100A10 and ANXA2 were also found to localize in the nucleus
	is predominantly cytoplasmic, and a much less but significant level is in the nucleus

basic FUNCTION	involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation
	within the endothelial cell, required for Src kinase-mediated tyrosine phosphorylation of ANXA2, which signals translocation of both proteins to the cell surface
	may play a role in the regulation of the proliferation or early maturation sequence of melanocytic lesions, and that it merits further study as a potential biomarker of activity
	function as a regulator of the filamentous actin network
	direct involvement of S100A10 in macrophage recruitment in response to inflammatory stimuli
	having a role in the antidepressant activity of neurotrophins
	is a pivotal regulator of depression-like behaviors and a mediator of antidepressant responses
	might play a critical role in antidepressant-induced hippocampal neurogenesis
	key cell surface receptor for plasminogen which regulates pericellular proteolysis and tumor cell invasion (
	plays a crucial role in the generation of plasmin leading to fibrinolysis, thus providing a link to the clinical hemorrhagic phenotype of Acute promyelocytic leukemia
	unable to bind calcium due to deletion and substitution of calcium-ligating residues
	key regulator of plasmin generation by cancer cells and macrophages
	important role for S100A10 in the regulation of fibrinolysis and angiogenesis, suggesting it plays a critical role in endothelial cell function
	plasminogen receptor S100A10 is essential for recruitment of macrophages to the tumor site
	required specifically for the migratory capability needed for tumor homing
	essential and sufficient for macrophage migration to tumor sites
	crucial role of S100A10 in actin dynamics promoting cell spreading via RAC1 activation
	is required for behavioral and cellular responses to selective serotonin reuptake inhibitors (SSRIs)
	S100A10, and not ANXA2, is the primary plasminogen receptor within the ANXA2-S100A10 complex and contributes to the plasmin-mediated effects that were originally ascribed to ANXA2b

CELLULAR PROCESS	cell cycle, progression

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

S100A10/ANXA2/HLTF pathway mediates both neurogenic and behavioral responses to selective serotonin reuptake inhibitors (SSRIs)

a component

constituent of epidermal differentiation complex

INTERACTION

DNA

RNA

small molecule	metal binding,
	calcium Ca2+

protein	like its binding partners S100A7 and annexin A2, is an oxidant-sensitive protein
	new binding partner of DLC1 (the 2 proteins colocalize in the cell cytoplasm and their binding is mediated by central sequences in the central domain of DLC1 and the C-terminus of S100A10)
	N-terminal acetylation of ANXA2 is required for S100A10 binding
	HLTF, chromatin-remodeling factor, is a target for the S100A10/ANXA2 heterotetrameric complex
	ANXA2 is a well-characterized binding partner for S100A10
	S100A10/ANXA2 not only increases the DNA-binding affinity of HLTF but also anchors HLTF to the nuclear matrix presumably via the interaction of ANXA2 with actin and PIP2
	ANXA2-S100A10 molecular bridge participates in cell-cell interactions, revealing a hitherto unexplored function of this protein interaction

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to major depression (minor role)

Variant & Polymorphism

Candidate gene	lipodystrophy and diabetes
Marker
Therapy target

ANIMAL & CELL MODELS

S100A10-null mice displayed increased deposition of fibrin in the vasculature and reduced clearance of batroxobin-induced vascular thrombi, suggesting a role for S100A10 in fibrinolysis