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FLASH GENE
Symbol S100A10 contributors: mct - updated : 14-04-2015
HGNC name S100 calcium binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11))
HGNC id 10487
Location 1q21.3      Physical location : 151.955.386 - 151.966.714
Synonym name
  • annexin II ligand, calpactin I, light polypeptide
  • annexin II tetramer (AIIt) p11 subunit
  • calpactin I light chain
  • cellular ligand of annexin II
    • Synonym symbol(s) ANX2LG, 2C, P11, p10, GP11, ANX2L, CAL1L, CLP11, 42C, ANX2L
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 11.33 kb     3 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (CAAT box)
    Binding site
    text structure two GAS sites, two AP-1 sites, two overlapping Sp-1 sites, and a gamma-IRE site (the proximal Sp-1/AP-2 site appears to be important for basal activity via its Sp-1 binding ability)
    MAPPING cloned Y linked N status confirmed
    Map cen - D1S442 - D1S2612 - D1S2347 - S100A10 - D1S305 - D1S506 - D1S484 - qter
    Authors White (99)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1069 - 97 - 2011 21269277
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver    
     pharynx   highly
    Hearing/Equilibriumear   highly
    Nervousbrainlimbic systemhippocampusdentate gyrus  Homo sapiens
    Reproductivefemale systembreastmammary gland highly
    Visualeyelens   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveinterstitialdermis  
    Epithelialbarrier/lining   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two calcium binding domains
  • an EF-hand motif
  • one S100 specific N ter
  • one classical C ter
    • mono polymer tetramer
    HOMOLOGY
    Homologene
    FAMILY S-100 family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • S100A10 and ANXA2 were also found to localize in the nucleus
  • is predominantly cytoplasmic, and a much less but significant level is in the nucleus
    • basic FUNCTION
  • involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation
  • within the endothelial cell, required for Src kinase-mediated tyrosine phosphorylation of ANXA2, which signals translocation of both proteins to the cell surface
  • may play a role in the regulation of the proliferation or early maturation sequence of melanocytic lesions, and that it merits further study as a potential biomarker of activity
  • function as a regulator of the filamentous actin network
  • direct involvement of S100A10 in macrophage recruitment in response to inflammatory stimuli
  • having a role in the antidepressant activity of neurotrophins
  • is a pivotal regulator of depression-like behaviors and a mediator of antidepressant responses
  • might play a critical role in antidepressant-induced hippocampal neurogenesis
  • key cell surface receptor for plasminogen which regulates pericellular proteolysis and tumor cell invasion (
  • plays a crucial role in the generation of plasmin leading to fibrinolysis, thus providing a link to the clinical hemorrhagic phenotype of Acute promyelocytic leukemia
  • unable to bind calcium due to deletion and substitution of calcium-ligating residues
  • key regulator of plasmin generation by cancer cells and macrophages
  • important role for S100A10 in the regulation of fibrinolysis and angiogenesis, suggesting it plays a critical role in endothelial cell function
  • plasminogen receptor S100A10 is essential for recruitment of macrophages to the tumor site
  • required specifically for the migratory capability needed for tumor homing
  • essential and sufficient for macrophage migration to tumor sites
  • crucial role of S100A10 in actin dynamics promoting cell spreading via RAC1 activation
  • is required for behavioral and cellular responses to selective serotonin reuptake inhibitors (SSRIs)
  • S100A10, and not ANXA2, is the primary plasminogen receptor within the ANXA2-S100A10 complex and contributes to the plasmin-mediated effects that were originally ascribed to ANXA2b
    • CELLULAR PROCESS cell cycle, progression
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • S100A10/ANXA2/HLTF pathway mediates both neurogenic and behavioral responses to selective serotonin reuptake inhibitors (SSRIs)
    • a component constituent of epidermal differentiation complex
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein
  • like its binding partners S100A7 and annexin A2, is an oxidant-sensitive protein
  • new binding partner of DLC1 (the 2 proteins colocalize in the cell cytoplasm and their binding is mediated by central sequences in the central domain of DLC1 and the C-terminus of S100A10)
  • N-terminal acetylation of ANXA2 is required for S100A10 binding
  • HLTF, chromatin-remodeling factor, is a target for the S100A10/ANXA2 heterotetrameric complex
  • ANXA2 is a well-characterized binding partner for S100A10
  • S100A10/ANXA2 not only increases the DNA-binding affinity of HLTF but also anchors HLTF to the nuclear matrix presumably via the interaction of ANXA2 with actin and PIP2
  • ANXA2-S100A10 molecular bridge participates in cell-cell interactions, revealing a hitherto unexplored function of this protein interaction
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to major depression (minor role)
    Variant & Polymorphism
    Candidate gene lipodystrophy and diabetes
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • S100A10-null mice displayed increased deposition of fibrin in the vasculature and reduced clearance of batroxobin-induced vascular thrombi, suggesting a role for S100A10 in fibrinolysis