SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,lumen
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,cytosolic
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| intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
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| text
| primarily localized to the ER, and it can form a complex with HSPA to regulate insulin receptor signaling at actin ruffles on the plasma membrane by acting as a negative regulator of phosphatidylinositol-3-kinase (PI3K) signaling |
| basic FUNCTION
| playing a negative role in regulating the actin cytoskeleton through hydrolyzing phosphatidyl inositol 4-5 biphosphate |
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hydrolyzes phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3] to downregulate intracellular levels |
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preferentially regulates glucose transport and actin cytoskeletal rearrangement among a variety of PI(3,4,5)P3 downstream events |
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with INPP5D and INPP5E, implicated in negatively regulating insulin signalling and glucose homoeostasis in specific tissues (Ooms 2009) |
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INPPK5 and INPPL1, inhibit actin cytoskeletal reorganization by opposing PI3K/Akt signaling  |
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is important for the control of the arginine vasopressin/aquaporin-2 signalling pathway and water transport in kidney collecting ducts |
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specific and prominent role of INPP5K in the regulation of insulin signaling |
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regulates MYOD1-mediated muscle differentiation |
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physiological role of PAK1-INPP5K binding in the regulation of insulin signaling in skeletal muscle |
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tumor suppressor activity of INPP5K and MYO1C, with overlapping roles in phosphoinositide (PI) 3-kinase/Akt signaling, known to be vital for the cell growth and survival |
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implicated in the regulation of insulin signaling in skeletal muscle |
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is essential for skeletal muscle structure and function |
