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FLASH GENE
Symbol GDF10 contributors: - updated : 11-04-2006
HGNC name growth differentiation factor 10
HGNC id 4215
Location 10q11.22      Physical location : 48.425.789 - 48.439.166
Synonym name
  • growth differentiation factor 10
  • bone morphogenetic protein 3B
  • Synonym symbol(s) BMP3B
    DNA
    TYPE functioning gene
    STRUCTURE 13.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure no TATA, CG rich
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumearinnercochlea highly
    Nervousbrain    
    Reproductivemale systemtestis   
    Respiratorylung    
     respiratory tractlarynx   
    Visualeyeretina   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    TGF-beta like domain
    mono polymer homomer , heteromer , dimer
    isoforms Precursor cleaved at a consensus Arg-X-X-Arg to yield a C terminus mature dimer
    HOMOLOGY
    interspecies homolog to Drosophila decapentaplegic-Vg,DVR family
    Homologene
    FAMILY
  • TGFB superfamily, BMP family
  • CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
    text secreted
    basic FUNCTION regulator of cell growth
    CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    text skeletal morphogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by cleaved by subtilisin like convertases
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS