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FLASH GENE
Symbol TUFT1 last update : 11-04-2006
HGNC name tuftelin 1
HGNC id 12422
Location 1q21-q23
Synonym name acidic enamelin protein
DNA RNA EXP/sub-loc PROTEIN PATHOLOGY
DNA
TYPE functioning gene
STRUCTURE 43.00 kb     13 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
cytosine-phosphate-guanine/HTF
Binding site   transcription factor
text structure several GC boxes and several transcription factor binding sites
MAPPING cloned Y linked   status provisional
Physical map
FLJ20519 1q21.3 hypothetical protein FLJ20519 SPEC1 1q21.2 hypothetical protein FLJ20519 AF1Q 1q21 hypothetical protein FLJ20519 MGC29891 1q21.3 hypothetical protein MGC29891 SEMA6C 1q21.2 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C FLJ23467 1q21.3 hypothetical protein FLJ23467 LOC388695 1 similar to hypothetical protein SB145 SCNM1 1q21.3 sodium channel modifier 1 TMOD4 1q12 tropomodulin 4 (muscle) TCFL1 1q21 transcription factor-like 1 PIP5K1A 1q22-q24 phosphatidylinositol-4-phosphate 5-kinase, type I, alpha PSMD4 1q21.3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 KIAA1441 1q21.3 KIAA1441 protein PIK4CB 1q21 phosphatidylinositol 4-kinase, catalytic, beta polypeptide RFX5 1q21 regulatory factor X, 5 (influences HLA class II expression) SELENBP1 1q21-q22 selenium binding protein 1 PSMB4 1q21 proteasome (prosome, macropain) subunit, beta type, 4 POGZ 1q21.1 pogo transposable element with ZNF domain CGN 1q21 cingulin TUFT1 1q21-q23 tuftelin 1 SNX27 1q21.3 sorting nexin family member 27 TNRC4 1q21 trinucleotide repeat containing 4 FLJ36032 1q21.3 hypothetical protein FLJ36032 MRPL9 1q21 mitochondrial ribosomal protein L9 OAZ3 1q21.3 ornithine decarboxylase antizyme 3 TDRKH 1q21 tudor and KH domain containing protein LOC339398 1q21.3 similar to DAAT9248 LOC388696 1 LOC388696 RORC 1q21 RAR-related orphan receptor C FLJ37964 1q21.3 hypothetical protein FLJ37964 CTMP 1q21 C-terminal modulator protein LOC391099 1 similar to keratin 8, type II cytoskeletal - human S100A10 1q21 S100 calcium binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11))
RNA
TRANSCRIPTS type messenger
EXPRESSION / SUBCELLULAR LOCALIZATION
EXPRESSION (based on citations) widely
constitutive of
   expressed in
organ(s)
SystemOrgan 1organ 2organ 3organ 4level
Digestiveliver    
 mouthtongue  highly
 pharynx   highly
Reproductivefemale systembreastmammary gland  
 male systemtestis   
Respiratorylung    
 respiratory tractlarynx  highly
tissue
SystemTissueS_TissueSs_Tissuelevel
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text tooth bud
SUBCELLULAR LOCALIZATION extracellular
text concentrated at the dentin-enamel junction and tightly bound to the surface of the growing crystallites
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a coiled-coil region
  • myosin-like globular head domain
  • one Iq domain
  • a myosin-like globular head domain
    • HOMOLOGY
    interspecies
     
    		 homolog to murine Tuft1
    intraspecies
     
    Homologene
    FAMILY
    CATEGORY regulatory , storage
    basic FUNCTION
  • playing a major role in the mineralization and structural organization of enamel
  • playing a role in cytokinesis, cell shape, and specialized functions such as secretion and capping
    • implicated in a
    process
    cellular process
    physiological
    pathway
    metabolism
    signaling
    a component
    structural
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacts with TFIP11
    cell & other
    REGULATION
    ASSOCIATED DISORDERS