protein
| GPRC6A is a candidate for mediating the response to BGLAP in the bone-pancreas endocrine loop regulating insulin signaling |
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unphosphorylated HSPB1 has an inhibitory effect on BGLAP synthesis, but has a stimulatory effect on mineralization, in osteoblasts |
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SP7 could act via the non-canonical Sp1/Sp3-binding element to regulate BGLAP transcription |
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TP53 can bind to the human osteocalcin promoter (may directly target the BGLAP and positively affect its gene expression) |
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BMP2 induces osteoblast differentiation through RUNX2-dependent ATF6 expression, which directly regulates BGLAP transcription |
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ATF4 activates BGLAP in osteoblasts and indian hedgehog (IHH) in chondrocytes |
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transforms adventitial fibroblasts to myofibroblasts through stimulating AGT release and subsequent activation of PKCD/TLR4/reactive oxygen species/cyclooxygenase-2 signaling cascade |
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NACA acts as a transcriptional coactivator of the Osteocalcin gene |
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regulates beta-cell replication in a cyclin D1-dependent manner by signaling through the GPRC6A receptor expressed in these cells |
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KDM6B plays important roles in osteoblast differentiation and regulates the expressions of IBSP and BGLAP via transcription factors RUNX2 and SP7 |
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ROCK1 negatively regulates BMP4-stimulated BGLAP synthesis via the MAPK14 pathway in osteoblasts |
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RBM3 has a role in enhancing the transcription of ALPP and BGLAP genes |