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FLASH GENE

Symbol

BCL2L13

contributors: mct/npt - updated : 30/09/2008

HGNC name	BCL2-like 13 (apoptosis facilitator)
HGNC id	17164

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	90.50 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	see ATP6V1E

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed MIL1FL 17 - 3367 52.7 485 - Olsen (2006) MIL1I1 - splicing 1390 - 104 ubiquitous Yi (2003) lack exon 8 Bcl-rambo beta - - - - 104 in lymph node, heart, and cervix but is absent in brain Yi (2003) contains a 98 bp Alu-like sequence which acts as an exon lacking of the BH1, BH2 and BH3 motifs and becomes a BH4-only protein not to be associated with mitochondria due to the absence of its C-terminal membrane anchor region having proapoptotic capability

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous nerve       highly Skin/Tegument skin       highly Visual eye       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	conserved Bcl-2 homology (BH) motifs 1, 2, 3, and 4
	C-terminal mitochondrial membrane anchor region

HOMOLOGY

Homologene

FAMILY

BCL2 family of apoptosis regulators

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,organelle,membrane
	intracellular,nucleus

basic FUNCTION

novel type of pro-apoptotic BCL2 member that triggers cell death independently of its BH motifs

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   induces apoptosis that is specifically blocked by the caspase inhibitors

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS