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FLASH GENE

Symbol

SARM1

contributors: mct/pgu - updated : 28-01-2016

HGNC name	sterile alpha and TIR motif containing 1
HGNC id	17074

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function exacerbates the progression of prion pathogenesis, by up-regulating XAF1, which promotes neuronal apoptosis, and accelerates prion disease

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurology     pharmacological inhibition of SARM1 may represent a promising therapeutic avenue for patients with axonal loss

ANIMAL & CELL MODELS

Sarm1-deficient mice may uncover unexpected similarities between the ways in which neurons and immune cells sense and respond to danger