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FLASH GENE
Symbol CHRDL1 contributors: mct/npt/pgu - updated : 26-05-2015
HGNC name chordin-like 1
HGNC id 29861
Corresponding disease
MGC1 megalocornea 1
Location Xq23      Physical location : 109.917.084 - 110.039.286
Synonym name
  • chordin-like
  • ventroptin
  • neuralin 1
  • neurogenesin-1
    • Synonym symbol(s) CHL, VOPT, NRLN1, dA141H5.1, MGC1, MGCN
    DNA
    TYPE functioning gene
    STRUCTURE 122.20 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 4101 - 458 - 2001 11118896
    12 - 4098 - 457 - 2001 11118896
    10 - 3858 - 377 - 2001 11118896
    12 - 3943 - 456 - 2001 11118896
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Urinarykidneynephron    Homo sapiens
    Visualeye     Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text
  • expressed in the developing human cornea and anterior segment in addition to the retina
  • differentially expressed in the human fetal brain, and there is high expression in cerebellum and neocortex
    • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • signal peptide, cysteine rich repeat
  • Von Willebrand factor type C domain
  • four chrd domains
  • three CR domains
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Chrdl1
    homolog to rattus Ng1
    intraspecies paralog to CHRDL2
    Homologene
    FAMILY
  • chordin family
  • bone morphogenetic protein (BMP) superfamily
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • determining and maintaining the regional specificity along the dorsal ventral (anteroposterior) axis of retina
  • may serve as an important BMP regulator for differentiating mesenchymal cells, especially during skeletogenesis, and for developing specific neurons
  • may function as a modulator of BMP signaling during embryonic development
  • plays a role in regulating angiogenesis
  • reduces BMP7 signaling in healthy renal proximal tubules, and the loss of this activity upon sloughing of injured epithelia promotes BMP7 signaling in repopulating, dedifferentiated epithelia
  • requirement for ventroptin during eye anterior segment development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
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