Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol HRASLS contributors: mct - updated : 06-12-2010
HGNC name HRAS-like suppressor
HGNC id 14922
Location 3q29      Physical location : 192.958.917 - 192.988.643
Synonym name
  • H-REV107 protein-related protein
  • human A-C1 Ha-Ras suppressor gene
  • Synonym symbol(s) A-C1, H-REV107, HRASLS1, HSD28
    DNA
    TYPE functioning gene
    STRUCTURE 29.72 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391604 3 similar to Probable ATP-dependent helicase DHX34 (DEAH-box protein 34) LOC344901 URP 3q29 urotensin II-related peptide C3orf6 3q29 chromosome 3 open reading frame 6 LOC152138 3q29 similar to PYRIN-containing APAF1-like protein 2 (NACHT-, LRR- and PYD-containing protein 2) (Nucleotide-binding site protein 1) LOC131086 3q29 similar to microtubule-associated protein 6 FGF12 3q29-qter fibroblast growth factor 12 LOC151963 3q29 similar to BcDNA:GH11415 gene product LOC285388 3q29 similar to vascular endothelial zinc finger 1 HRASLS 3q28-q29 HRAS-like suppressor DKFZp761I1011 3q29 hypothetical protein DKFZp761I1011 OPA1 3q28-q29 optic atrophy 1 (autosomal dominant) LOC389186 3 LOC389186 HES1 3q28-q29 hairy and enhancer of split 1, (Drosophila) LOC254808 3q29 hypothetical protein LOC254808 LOC285280 3q29 similar to Carboxypeptidase N 83 kDa chain (Carboxypeptidase N regulatory subunit) LRRC15 3q29 leucine rich repeat containing 15 GP5 3q29 glycoprotein V (platelet) AFURS1 3q29 ATPase family homolog up-regulated in senescence cells LOC391605 3 similar to 60S ribosomal protein L23a LOC93109 3q29 hypothetical protein BC007772 FLJ11301 3q29 hypothetical protein FLJ11301 FLJ90022 3q29 hypothetical protein FLJ90022 LOC285303 3q29 similar to MGC27169 protein FLJ35155 3q29 hypothetical protein FLJ35155 CENTB2 3q29 centaurin, beta 2 PPP1R2 3q29 protein phosphatase 1, regulatory (inhibitor) subunit 2 LOC391606 3 similar to ribosomal protein L24 LOC255812 3q29 hypothetical protein LOC255812 LOC389187 3 LOC389187
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1075 - 168 - 2001 11474175
    EXPRESSION
    Rna function mRNA was expressed in skeletal muscle, testis, heart, brain, and thyroid
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrinethyroid    
    Nervousbrain    
    Reproductivemale systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines highly in osteosarcoma derived U20S cells
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal catalytic domain having a similar architecture to classical NlpC/P60 domains, even though their fold topologies are different due to circular permutation in the primary sequence
  • two consensus sequences
  • PXXG involved in binding to Mg2+ and gamma-phosphate when GTP is bound
  • NKXD important for binding guanine ring
  • HOMOLOGY
    interspecies ortholog to murine A-C1
    Homologene
    FAMILY
  • H-REV107-like family
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    intracellular,nuclear envelope,lumen
    basic FUNCTION
  • modulator of Ras signaling pathway
  • Ca(2+)-independent phospholipase A(1/2), and it is also a pro-apoptosis protein
  • essential enzyme in retinol metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    Ras signaling pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • GTP
  • magnesium Mg2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    silenced in human gastric cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS