protein
| SRE of FOS, in cooperation with ATF6 and transiently activating FOS transcription |
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myocardin (MYOCD) |
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TEAD1 through the MADS domain to coactivate the skeletal alpha-actinin promoter |
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interacting with ZIC3 (physically and functionally associate with ZIC3 suggesting that it may play a role as a mediator of its activities in mesoderm and committed cardiac lineages) |
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interaction with FOXK1 (important for the regulation of the SRF target genes SM alpha-actin and PPGB) |
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CCAAT/enhancer-binding protein-beta |
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CRP1, CRP2 and GATA |
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ELK1, SAP1a, FLI1, EWS-FLI1, ETS1, ETS2, PEA3 and PU.1 proteins can form ternary complexes with SRF on the Egr1 SREI and II |
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spindlin (SPIN), homeodomain-only protein (HOP) |
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TEA/ATTS DNA-binding domain of transcription enhancer factor-1 |
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steroid receptor coactivator-1 (SRC-1) and p300 |
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SSRP1 (structure-specific recognition protein) |
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NF-kappaB subunit p65, Nkx-2.5 |
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homologue of the Drosophila NK-3 homeodomain gene bagpipe (Nkx3-1) |
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subunit of nuclear factor-Y (NF-YA) |
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myogenin-E12 |
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megakaryoblastic leukemia-1 and 2 (MKL1, MKL2) |
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high mobility group at-hook 1 (HMGA1) |
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cysteine-rich LIM-only proteins, CRP1 and CRP2 |
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activating transcription factor 6 (ATF6) |
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TEA/ATTS DNA-binding domain of transcription enhancer factor-1 |
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PEA3-binding factor, p35C/EBPbeta and p20C/EBPbeta |
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barH-like homeobox 2b (BARX2b) |
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interaction with PDLIM3 |
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human activating signal cointegrator 1 (hASC-1) |
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interacting with KLF3 (SRF may regulate many striated- and smooth-muscle genes that lack known SRF control elements) |
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essential co-regulator of the CKM and genes encoding sarcomeric proteins in the adult heart |
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LMOD1 is a Smooth muscle cell-restricted SRF/MYOCD target gene |
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overexpression of SRF induced RUNX2 transactivity in control cells and restored RUNX2 transactivity in the SRF-deficient cells) |
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MYOCD functions as a transcriptional coactivator of SRF and is sufficient and necessary for smooth muscle gene expression |
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dysfunction of MKL2 and its transcriptional coactivation partner, SRF, was supported by a decrease in gene and protein expression of CDK16, a downstream target of MKL2:SRF heterodimer transcriptional activation |
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TEAD1 is a novel general repressor of smooth muscle-specific gene expression through interfering with MYOCD binding to SRF |
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ACTR5 bound to a DNA binding domain of SRF via its C-terminal sequence and prevented the association of the MYOCD-SRF complex with the promoter regions of smooth muscle genes |
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GSK3B binds to and directly phosphorylates SRF on a highly conserved serine residue |
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SRF utilizes MKL1/2 to fulfill steady state cellular functions, including cytoskeletal organization, and utilizes ELK4 to facilitate acute responses to external infection |
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SRF regulates craniofacial development through selective recruitment of MKL1 cofactors by PDGF signaling |
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MYOCD is a co-factor of serum response factor (SRF) and is considered to be the master regulator of VSMC differentiation |
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it is likely that SRF-ICA1L fusions define a similar subset of neoplasms composed of immature smooth muscle cells |
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TCF21 blocks MYOCD and SRF association by direct TCF21-MYOCD interaction in smooth muscle cell differentiation |