SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,cytoplasm,organelle,endosome
|
| intracellular,cytoplasm,organelle,lysosome
|
text
| multi-pass membrane protein |
basic FUNCTION
| delivering the nucleotide-sensing receptors TLR7 and TLR9 from the endoplasmic reticulum (ER) to the endolysosomes |
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can control the functional pool of TLR9 by regulating exit from the ER |
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with CNPY3, and HSP90B21, play a role in TLR localisation |
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critical role for UNC93B1 on induction of IL12/IFNG production as well as autonomous control of Toxoplasma replication by macrophages |
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upon activation, TLR7 and 9 are transported from the endoplasmic reticulum (ER) to endolysosomes for nucleic acid sensing by an ER-resident protein, UNC93B1 |
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participates in intracellular trafficking and signaling for all nucleotide-sensing TLRs, but the mode of regulation of TLR localization differs for each TLR |
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involved in Toll-like receptor activation |
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UNC93B1 expression is required for TLR3 cleavage and signaling |
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multipass transmembrane protein required for TLR3, TLR7, TLR9, TLR11, TLR12, and TLR13 function, controls trafficking of TLRs from the endoplasmic reticulum (ER) to endolysosomes |
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essential for trafficking of endosomal TLRs from the endoplasmic reticulum to endosomes |