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FLASH GENE
Symbol ARHGAP9 contributors: mct/npt - updated : 15/09/2008
HGNC name Rho GTPase activating protein 9
HGNC id 14130
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 - 2614 - 731 - Peck (2002)
16 - 2604 - 640 - Peck (2002)
16 - 2102 - 547 - Peck (2002)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   highly
 thymus   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • SRC homology 3 domain
  • RHO GAP domain
  • a pleckstrin homology domain
  • a WW domain
    • HOMOLOGY
    Homologene
    FAMILY
  • Rho GTPase activating family
    • CATEGORY adhesion , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • regulation of adhesion of hematopoietic cells to extracellular matrix
  • having a function to catalyze the hydrolysis of GTP that is bound to Rho, Rac and/or Cdc42, inactivating these regulators of the actin cytoskeleton
    • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to coronary artery spasm
    Variant & Polymorphism other Ala370Ser polymorphism in the ARHGAP9 gene is associated with coronary artery spasm (Takefuji 2010)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS