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FLASH GENE

Symbol

GFM1

contributors: mct - updated : 23-04-2013

HGNC name	G elongation factor, mitochondrial 1
HGNC id	13780

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	48.04 kb     18 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_024996 18 - 3468 NP_079272 - 751 - 2001 11374907

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Reproductive male system testis

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	consensus GTP binding domain composed of three motifs
	potential phosphorylation sites

conjugated

PhosphoP

HOMOLOGY

interspecies	homolog to murine Gfm1 (91.2pc)
	homolog to rattus Gfm (91.2pc)

Homologene

FAMILY

GTP-binding elongation factor family, EG-G/EF-2 subfamily

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,nucleus
text	nuclear gene encoding mitochondrial protein

basic FUNCTION	promotes the GTP-dependent translocation of the nascent protein from the A-site to the P-site of the ribosome
	playing a role in the regulation of normal mitochondrial function

CELLULAR PROCESS	nucleotide, transcription, elongation
	protein

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

binding

small molecule	nucleotide,
	GTP binding

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

OXPHOSD1

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS