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FLASH GENE
Symbol GFM1 contributors: mct - updated : 23-04-2013
HGNC name G elongation factor, mitochondrial 1
HGNC id 13780
Corresponding disease
OXPHOSD1 mitochondrial oxidative phosphorylation deficiency 1
Location 3q25.32      Physical location : 158.362.316 - 158.410.358
Synonym name
  • elongation factor G1
  • mitochondrial elongation factor 6
  • G translation elongation factor, mitochondrial
    • Synonym symbol(s) EFG, GFM, EFG1, EFGM, FLJ12662, FLJ13632, FLJ20773, EGF1, COXPD1
    DNA
    TYPE functioning gene
    STRUCTURE 48.04 kb     18 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 3468 - 751 - 2001 11374907
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Reproductivemale systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • consensus GTP binding domain composed of three motifs
  • potential phosphorylation sites
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Gfm1 (91.2pc)
    homolog to rattus Gfm (91.2pc)
    Homologene
    FAMILY GTP-binding elongation factor family, EG-G/EF-2 subfamily
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    text nuclear gene encoding mitochondrial protein
    basic FUNCTION
  • promotes the GTP-dependent translocation of the nascent protein from the A-site to the P-site of the ribosome
  • playing a role in the regulation of normal mitochondrial function
    • CELLULAR PROCESS nucleotide, transcription, elongation
    protein
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule nucleotide,
    GTP binding
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) OXPHOSD1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS