SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytosolic
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| intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
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| text
| cytoplasmic phosphorylated form |
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nuclear after activation controlled by calcineurin-mediated dephosphorylation |
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nuclear in skeletal muscle, but a predominantly cytosolic localization in other tissues  |
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remains phosphorylated and localized to the cytosol, only exhibiting nuclear localization following prolonged (1-3 h) depolarization |
| basic FUNCTION
| regulate cytokine gene expression in T cells (to suppress local aberrant growth of vessels) |
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required for cardiac development and mitochondrial function |
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involved in adipocyte differentiation |
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playing a role in learning and memory |
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mediating myotube differentiation after activation by RPS6KA3 |
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implicated as a critical regulator of the cardiac development and hypertrophy |
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having an unexpected role as a direct transcriptional repressor of GAP43 expression and may be a more general role in the control of the neuronal outgrowth program |
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negative and not a positive regulator of GAP43 during neuronal outgrowth and maturation |
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occupies the GAP43 promoter and neurotrophin stimulation reduces promoter occupancy |
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may be having the potential to regulate the expression of other genes involved in neuronal outgrowth and maturation |
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may plays a role in axonal regeneration after axotomy by controlling the gene expression of neuronal outgrowth genes |
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transcriptionally active in fast muscles, i.e., in response to less frequent calcium transients and, presumably, lower Calcineurin activity |
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inhibits breast cancer cell motility by targeting the LCN2 gene |
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opposing transcriptional activities of FOXP1 and NFATC4 maintaining cardiomyocyte homeostasis |
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NFATC4 calcineurin-dependent activity is required selectively for survival of adult-born neurons in response to BDNF signaling (pMID: 22586092) |
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is essential in the regulation of adult hippocampal neurogenesis and is a central player of BDNF–driven prosurvival signaling in hippocampal adult-born neurons |
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may play a role in promoting the brain secondary damage following intracerebral hemorrhage (ICH) |
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NFATC4 might exert its pro-apoptotic function in neuronal apoptosis through extrinsic pathway |
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is a key activity-dependent transcriptional regulator of GABA signaling in hippocampal progenitor cells |
