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FLASH GENE
Symbol TXNRD2 contributors: mct - updated : 19-10-2022
HGNC name thioredoxin reductase 2
HGNC id 18155
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a mitochondrial leading sequence (MLS)
  • selenocysteine residue at the C terminus, conserved active site CVNVGC, and the FAD-binding and NADPH binding domain
  • mono polymer homomer , dimer
    isoforms Precursor
    HOMOLOGY
    intraspecies homolog to TRXR1
    Homologene
    FAMILY family of pyridine nucleotide-disulfide oxidoreductases
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • thioredoxin reductase activity
  • participates in the regulation of protein tyrosine phosphorylation and cell growth
  • play essential roles in cell survival and mitochondria-mediated apoptosis
  • TXNRD2 plays a vitally important role in balancing mitochondrial ROS production in the endothelium.
  • overexpression of mitochondrial TXNRD2 in Drosophila melanogaster extended median (but not maximum) lifespan in female flies with a small lifespan extension in males
  • selenium-dependent oxidoreductases TXNRD1 and TXNRD2 should be considered as key components of signaling pathways that control cell differentiation and cellular stress responses
  • CELLULAR PROCESS cell cycle, progression
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GPX2, TXNRD2 and TXNRD3 are regulated by WNT signalling in the intestinal epithelium
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CMD1LL , GCCD5
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in in dilated cardiomyopathy
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • cardiac-specific deletion of Txnrd2 in mice results in dilated cardiomyopathy (DCM)