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FLASH GENE

Symbol

TXNRD2

contributors: mct - updated : 19-10-2022

HGNC name	thioredoxin reductase 2
HGNC id	18155

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Homo sapiens Digestive intestine small intestine       Reproductive female system uterus         male system testis       Urinary kidney         Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum       Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a mitochondrial leading sequence (MLS)
	selenocysteine residue at the C terminus, conserved active site CVNVGC, and the FAD-binding and NADPH binding domain

mono polymer

homomer , dimer

isoforms

Precursor

HOMOLOGY

intraspecies

homolog to TRXR1

Homologene

FAMILY

family of pyridine nucleotide-disulfide oxidoreductases

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,matrix
	intracellular,cytoplasm,cytosolic

basic FUNCTION	thioredoxin reductase activity
	participates in the regulation of protein tyrosine phosphorylation and cell growth
	play essential roles in cell survival and mitochondria-mediated apoptosis
	TXNRD2 plays a vitally important role in balancing mitochondrial ROS production in the endothelium.
	overexpression of mitochondrial TXNRD2 in Drosophila melanogaster extended median (but not maximum) lifespan in female flies with a small lifespan extension in males
	selenium-dependent oxidoreductases TXNRD1 and TXNRD2 should be considered as key components of signaling pathways that control cell differentiation and cellular stress responses

CELLULAR PROCESS	cell cycle, progression
	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

GPX2, TXNRD2 and TXNRD3 are regulated by WNT signalling in the intestinal epithelium

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CMD1LL , GCCD5

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       in in dilated cardiomyopathy

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

cardiac-specific deletion of Txnrd2 in mice results in dilated cardiomyopathy (DCM)