basic FUNCTION
| thioredoxin reductase activity |
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participates in the regulation of protein tyrosine phosphorylation and cell growth |
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play essential roles in cell survival and mitochondria-mediated apoptosis |
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TXNRD2 plays a vitally important role in balancing mitochondrial ROS production in the endothelium. |
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overexpression of mitochondrial TXNRD2 in Drosophila melanogaster extended median (but not maximum) lifespan in female flies with a small lifespan extension in males |
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selenium-dependent oxidoreductases TXNRD1 and TXNRD2 should be considered as key components of signaling pathways that control cell differentiation and cellular stress responses |