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FLASH GENE
Symbol ALOX12B contributors: mct - updated : 02-02-2007
HGNC name arachidonate 12-lipoxygenase, 12R type
HGNC id 430
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a PLAT/LH2 domain (beta-barrel domain)
HOMOLOGY
interspecies ortholog to murine Alox12b
ortholog to chimpanzee alox12b
intraspecies homolog to ALOX15B
homolog to ALOXE3
Homologene
FAMILY lipoxygenase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • first step of leukotrienes synthesis from arachidonate
  • converting arachidonic acid to 12R-hydroperoxy eicosatetraenoic acid (12R-HPETE)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , inflammation , endocytosis transport , electron transport
    text
  • epidermis development
    • PATHWAY
    metabolism lipid/lipoprotein
    signaling
  • leukotriene biosynthesis
    • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    iron Fe2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NCIE3B
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS