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FLASH GENE
Symbol ALOX12B contributors: mct - updated : 02-02-2007
HGNC name arachidonate 12-lipoxygenase, 12R type
HGNC id 430
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem, component of a cluster
text arranged in a head-to-tail fashion separated by 8.5 kb with ALOX12B
STRUCTURE 15.00 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx    
Lymphoid/Immunelymph node    
Reproductivefemale systemuteruscervix  
Skin/Tegumentskin    
Urinarybladder    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneB cell
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a PLAT/LH2 domain (beta-barrel domain)
HOMOLOGY
interspecies ortholog to murine Alox12b
ortholog to chimpanzee alox12b
intraspecies homolog to ALOX15B
homolog to ALOXE3
Homologene
FAMILY lipoxygenase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • first step of leukotrienes synthesis from arachidonate
  • converting arachidonic acid to 12R-hydroperoxy eicosatetraenoic acid (12R-HPETE)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , inflammation , endocytosis transport , electron transport
    text
  • epidermis development
    • PATHWAY
    metabolism lipid/lipoprotein
    signaling
  • leukotriene biosynthesis
    • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    iron Fe2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NCIE3B
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS