Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ALOXE3 contributors: np/ - updated : 28-09-2013
HGNC name arachidonate lipoxygenase 3
HGNC id 13743
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • characteristic segment of 41 aa wich be located beyond the N terminal beta barrel domain at the surface of the C terminal catalyting domain
  • PLAT/LH2 domain
    • HOMOLOGY
    interspecies ortholog to murine Aloxe3
    intraspecies homolog to ALOX12B
    homolog to ALOX15B
    Homologene
    FAMILY
  • lipoxygenase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • first step of leukotrienes synthesis from arachidonate
  • introducing molecular oxygen into polyunsaturated fatty acids
  • synergistic action with XDH, group of oxidized fatty acids which can function as PPAR{gamma} activators
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation , electron transport
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • iron Fe2+
    • protein
  • functional link with ALOX12 in normal differentiation of the epidermis
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ARCI3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS