Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ALOXE3 contributors: np/ - updated : 28-09-2013
HGNC name arachidonate lipoxygenase 3
HGNC id 13743
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Urinarybladder    
 kidney    
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
not specificadipocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • characteristic segment of 41 aa wich be located beyond the N terminal beta barrel domain at the surface of the C terminal catalyting domain
  • PLAT/LH2 domain
    • HOMOLOGY
    interspecies ortholog to murine Aloxe3
    intraspecies homolog to ALOX12B
    homolog to ALOX15B
    Homologene
    FAMILY
  • lipoxygenase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • first step of leukotrienes synthesis from arachidonate
  • introducing molecular oxygen into polyunsaturated fatty acids
  • synergistic action with XDH, group of oxidized fatty acids which can function as PPAR{gamma} activators
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation , electron transport
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • iron Fe2+
    • protein
  • functional link with ALOX12 in normal differentiation of the epidermis
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ARCI3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS