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FLASH GENE
Symbol ALOX15B contributors: - updated : 21-04-2005
HGNC name arachidonate 15-lipoxygenase, second type
HGNC id 434
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemprostate  highly
Respiratorylung    
Skin/Tegumentskin appendageshairfollicle  
Visualeyeanterior segmentcornea  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a potential bi-partite nuclear localization signal (NLS) at the N-terminus
  • PLAT/LHA2 domain
    • HOMOLOGY
    intraspecies homolog to ALOXE3
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    basic FUNCTION
  • catalyzing the first step of leukotrienes from arachidonate
  • suppressing prostate tumor development, and the tumor-suppressive functions apparently not depending on AA-metabolizing activity and nuclear localization
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    iron Fe2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS