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FLASH GENE
Symbol CD320 contributors: mct - updated : 22-01-2009
HGNC name CD320 molecule
HGNC id 16692
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal sequence
  • an extracellular region with two LDL-receptor class A domains
  • a transmembrane domain
  • a short cytoplasmic tail
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Cd320 (64.6 pc)
    homolog to murine Cd320 (60.6 pc)
    Homologene
    FAMILY
    CATEGORY antigen , signaling growth factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • augmenting the proliferation of plasma cells precursors generated by IL-10 (Zhang 2001)
  • putatively mediating follicular dendritic cells (FDC) in the germinal center stimulation of B cell growth
    • CELLULAR PROCESS cell life, proliferation/growth
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text cell growth regulation
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other the cell cycle associated expression of CD320 appears to be tightly regulated in synchrony with the proliferative phase of the cell cycle
    ASSOCIATED DISORDERS
    corresponding disease(s) MMA
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    down-regulation of CD320 or blocking CBL uptake in cancer cells are strategies likely to arrest proliferation of cancer cells
    ANIMAL & CELL MODELS