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FLASH GENE

Symbol

USP5

contributors: mct - updated : 15-04-2021

HGNC name	ubiquitin specific protease 5 (isopeptidase T)
HGNC id	12628

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       gain of function in hepatocellular carcinoma (HCC) cells constitutional     --other   dysregulation of USP5 SUMOylation after peripheral nerve injury may contribute to the well described alteration in CACNA1H activity during neuropathic pain states

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	may serve as a novel prognostic biomarker in non-small cell lung cancer (NSCLC)
Therapy target
	System Type Disorder Pubmed miscelleaneous pain   enhancement of CACNA1H currents in afferent neurons is mediated by deubiquitination of the channels by the deubiquitinase USP5, and disrupting USP5/CACNA1H interactions protected from inflammatory and neuropathic pain cancer lung   potential target for the treatment of metastasis in NSCLC

ANIMAL & CELL MODELS