| basic FUNCTION
| mediating the uptake of IgG from milk |
|
involved in the transport of maternal IgG to the fetus, and protection of circulating IgG from catabolism |
|
expressed in podocytes and functions to internalize IgG from the glomerular basement membrane (GBM) |
|
major histocompatibility complex class I-related molecule that regulates the half-life of IgG and albumin |
|
FCGRT expression has a different effect on Ag processing and presentation of immune-complex to CD4(+) T cells in the endosomal versus phagosomal compartments of macrophages (Ms) versus dendritic cells |
|
IgG is transcytosed across intestinal epithelial cells of suckling mammals by the neonatal Fc receptor FCGRT |
|
prevents IgG degradation by efficiently sorting IgG into recycling endosomes and away from lysosomes |
|
physical properties of the lumenal ligand-receptor complex appear to act as key determinants for sorting between the recycling and lysosomal pathways by regulating FGRT entry into recycling tubules |
|
plays a critical role in the homeostasis and degradation of immunoglobulin G (IgG) |
|
has the potential to interact with IgG-Fc domains in the ciliary epithelium and retinal and choroidal vasculature |
|
possible involvement of promoter binding transcription factors (TFs) in the regulation of the human FCGRT gene expression |
|
role of FCGRT in IgG transcytosis in the nasal epithelium |
|
serum albumin is the most abundant plasma protein and has a long half-life due to neonatal FCGRT-mediated transcytosis by many cell types, including proximal tubule cells of the kidney |
|
may be associated with the transport and metabolism of IgG in thyrocytes and this transport is independent of IgG type |
|
may be involved in Hashimoto's thyroiditis (HT) pathogenesis |
