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FLASH GENE
Symbol FBXL7 contributors: npt/ - updated : 21-09-2004
HGNC name F-box and leucine-rich repeat protein 7
HGNC id 13604
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal serine-rich region
  • 40AA F-box motif l
  • twelve leucine-rich repeats (LRR) cysteine-containing subfamily at C terminus
    • HOMOLOGY
    Homologene
    FAMILY
  • F-box protein family
    • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • phosphorylation dependent uniquination
  • substrate recognition subunit of SCF ubiquitin protein ligase complex
    • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • one of the four subunits of the E3 ubiquitin protein ligase complex :(SCF) with SKP1, CUL1, RBX1, F-box protein bringing ubiquitin conjugating enzymes to substrates recruited by F-box
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • various target proteins
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS