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FLASH GENE
Symbol FBXL4 contributors: mct - updated : 26-09-2012
HGNC name F-box and leucine-rich repeat protein 4
HGNC id 13601
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal mitochondrial targeting sequence (MTS) essential to target FBXL4 to mitochondria
  • F-box 40AA domain
  • a canonical FBXL functional domains
  • a AMN1 domain
  • a C terminal nine leucine-rich repeats (LRR), ribonuclease inhibitor type
    • HOMOLOGY
    Homologene
    FAMILY F-box protein family
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,interspace
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • F-box protein that colocalizes with mitochondria
    • basic FUNCTION
  • phosphorylation dependent uniquination
  • substrate recognition subunit of SCF ubiquitin protein ligase complex
  • mitochondrial protein with a possible role in maintaining mtDNA integrity and stability
  • role for FBXL4 in controlling bioenergetic homeostasis and mtDNA maintenance
    • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • one of the four subunits of the E3 ubiquitin protein ligase complex :(SCF) with SKP1, CUL1, RBX1, F-box protein bringing ubiquitin conjugating enzymes to substrates recruited by F-box
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • various target proteins
  • FBXL4 interacted with KDM4A and regulated protein turnover
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MTDPS13
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS